Nav1.1 topology

Secondary protein structure:  boundaries of membrane spanning element as defined by Escayg et al., 2000.

Amino acid
START
Amino acid
END
Topology
1 123 N-terminus
124 147 D1/S1
148 155 D1/S1-S2ex
156 175 D1/S2
176 188 D1/S2-S3in
189 207 D1/S3
208 213 D1/S3-S4ex
214 233 D1/S4
234 249 D1/S4-S5in
250 273 D1/S5
274 399 P1
400 425 D1/S6
426 762 L1
763 787 D2/S1
788 798 D2/S1-S2ex
799 822 D2/S2
823 830 D2/S2-S3in
831 850 D2/S3
851 856 D2/S3-S4ex
857 876 D2/S4
877 892 D2/S4-S5in
893 913 D2/S5
914 966 P2
967 992 D2/S6
993 1213 L2
1214 1237 D3/S1
1238 1250 D3/S1-S2ex
1251 1276 D3/S2
1277 1282 D3/S2-S3in
1283 1304 D3/S3
1305 1308 D3/S3-S4ex
1309 1330 D3/S4
1331 1349 D3/S4-S5in
1350 1371 D3/S5
1372 1456 P3
1457 1483 D3/S6
1484 1536 L3
1537 1560 D4/S1
1561 1571 D4/S1-S2ex
1572 1595 D4/S2
1596 1601 D4/S2-S3in
1602 1625 D4/S3
1626 1635 D4/S3-S4ex
1636 1657 D4/S4
1658 1672 D4/S4-S5in
1673 1695 D4/S5
1696 1761 P4
1762 1786 D4/S6
1787 2009 C-terminus